Beilstein J. Org. Chem.2014,10, 2677–2682, doi:10.3762/bjoc.10.282
derived from Ginkgobiloba. Its structure was unambiguously established by analysis of HRMS–ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu Kα radiation. This compound is structurally characterized by a new
, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.
Keywords: Aspergillus; endophytic fungus; Ginkgobiloba; natural product; norditerpenoid; Trichocomaceae; Introduction
Plant-derived fungi, which have drawn considerable attention from natural product chemists, have been proved
previous chemical investigation of the bioactive secondary metabolites produced by the endophytic Aspergillus sp. YXf3 associated with Ginkgobiloba led to the isolation of new p-terphenyls and novel types of diterpenoids including pimarane-type diterpenoids (sphaeropsidins A and B, aspergiloids D and E
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Graphical Abstract
Figure 1:
Structure of aspergiloid I (1) and its novel skeleton.